Manganese Whole Blood

Manganese

(Biochemistry)

Investigation

Manganese

Specimen type

Whole Blood

Spec container

EDTA

Volume required

4 ml

Reference range

70 - 280 nmol/L

Turnaround

<5 days

Whole blood lithium heparin samples also accepted.
Whole blood Manganese levels give an indication of chronic exposure.

Reference Range

Whole blood Manganese 70 - 280 nmol/L

Deficiency Although deficiency states are clearly documented in some animal species, evidence of deficiency in humans is less well defined.

Toxicity >360 nmol/L Potentially toxic levels. As excess manganese is excreted in the bile, this may occur where there is biliary stasis, particularly in patients on TPN. Manganese accumulation in the brain, may cause ‘Manganese-induced Parkinsonism’

Additional information on manganese and its clinical use can be found here: manganese.
For NICE Guidelines click here.

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	Reference Range
Whole blood Manganese	70 - 280 nmol/L
Deficiency	Although deficiency states are clearly documented in some animal species, evidence of deficiency in humans is less well defined.
Toxicity	>360 nmol/L Potentially toxic levels. As excess manganese is excreted in the bile, this may occur where there is biliary stasis, particularly in patients on TPN. Manganese accumulation in the brain, may cause ‘Manganese-induced Parkinsonism’